Epilepsy & Seizures
Aug. 18, 2021
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For pyruvate dehydrogenase (R=H). For alpha-ketoglurate (R=CH2-COO-). Step A is the E1k-mediated decarboxylation step, utilizing TPP as a cofactor. Steps B and C are E2k-mediated sequential succinylation steps, ultimately forming succinyl CoA and utilizing lipoamide and coenzyme A as cofactors. Steps D and E are E3-mediated electron transfer reactions that utilize FAD and NAD as cofactors. (Courtesy of Wikimedia Commons. Public domain.)