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  • Updated 03.28.2021
  • Released 03.28.2005
  • Expires For CME 03.28.2024



Historical note and terminology

Duloxetine hydrochloride was originally developed as an antidepressant for the treatment of major depressive disorder including both the emotional and physical symptoms. Later it was found to be effective for the relief of neuropathic pain in diabetic neuropathy; it was approved for this indication by the FDA in 2004 and is the focus of this article. The generic name, duloxetine, is the most used name worldwide. Of the numerous trade names, the best known is Cymbalta.

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