Epilepsy & Seizures
Inhibitory motor seizures
Apr. 26, 2021
Nearly 3,000 illustrations, including video clips of neurologic disorders.
Every article is reviewed by our esteemed Editorial Board for accuracy and currency.
Full spectrum of neurology in 1,200 comprehensive articles.
Note the binding of protective antigen to anthrax toxin receptors on the cell surface, with subsequent proteolytic processing and oligomerization to form a heptamer, which binds edema factor and lethal factor. LF and EF can bind to the PA heptamer (PA7mer) to form lethal toxin (LT) or edema toxin (ET), which associate with lipid rafts. These complexes are then internalized via endocytosis, and through a translocation process lethal factor and edema factor can enter the cytoplasm. (Source: Bower WA, Hendricks K, Pillai S, Guarnizo J, Meaney-Delman D, Centers for Disease Control and Prevention (CDC). Clinical framework and medical countermeasure use during an anthrax mass-casualty incident. MMWR Recomm Rep 2015;64(4):1-22. Public domain.)