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Folate 1-carbon metabolism basic steps

The interrelationships of the enzymes involved in basic folate one-carbon metabolism. Some of the basic steps in folate one-carbon metabolism. Abbreviations (in alphabetic order): DHFR, dihydrofolate reductase; MTHFD, methylenetetrahydrofolate dehydrogenase; MHTFR, methylenetetrahydrofolate reductase; MTHFS, methenyl-tetrahydrofolate synthetase; SHMT, serine hydroxymethyltransferase; THF, tetrahydrofolate. (Image by Douglas Lanska MD MS MSPH.)

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