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Pedigree of the patient with Fabry disease reported by Anderson (1898)

The pedigree spans seven generations and includes six affected males and seven obligate female carriers. Symbols: circle, female; square, male; dotted circle, obligate female carrier; filled square, diseased male; arrow, propositus (II-2). (Source: Gaggl M, El-Hadi S, Aigner C, Sunder-Plassmann G. The renal history of Fabry disease. G Ital Nefrol 2016;33 Suppl 66:33.S66.14. Modified by Dr. Douglas J Lanska.)

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Associated Disorders

  • Atypical heterozygotes
  • Autonomic neuropathy
  • Cerebral infarction
  • Glycosphingolipidosis
  • Hypertrophic cardiomyopathy
  • Myocardial infarction
  • Renal failure