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Lipid accumulation in small sensory neurons of dorsal root ganglia seen with luxol-blue staining. (Contributed by Dr. Edward Kaye.)
Headache & Pain
Aug. 22, 2021
Stroke & Vascular Disorders
Genetic and acquired hypercoagulable states, such as factor V Leiden deficiency and antiphospholipid syndrome, are associated with cerebrovascular events, including cerebral venous thrombosis and ischemic stroke. The clinical manifestations of thrombophilic patients can be due to either venous thrombosis or (rarely) arterial thrombosis. The most common presentation of venous thrombosis is deep vein thrombosis of the lower extremity with or without pulmonary embolism.
Aug. 27, 2021
Nov. 30, 2020
Chronic fatigue syndrome is generally characterized by extreme fatigue that lasts for at least six months, cannot be fully explained by an underlying medical condition, worsens with physical or mental activity, and does not improve with rest. Symptoms are not homogeneous, and almost every patient has a unique and fluctuating constellation of symptoms. It is also known as myalgic encephalomyelitis or chronic fatigue immune dysfunction syndrome.
Jan. 09, 2020
Childhood Degenerative & Metabolic Disorders
Dec. 29, 2020
Oct. 21, 2020
Stereotypies are considered purposeless, fixed forms of expression or response that may interfere with normal behavior. Stereotypies may represent a transient phenomenon in children, but may be associated with a variety of severe neurologic disorders, including specific biochemical disorders, such as Rett syndrome and Lesch Nyhan disease, and the whole spectrum of autistic disorders and pervasive developmental disorders. Stereotypic disorders may require intervention, especially when harmful, but often do not. Treatment is highly individualized.
Nov. 21, 2020
Malignant hyperthermia is a hypermetabolic response to potent inhalational agents and/or succinylcholine that can lead to death. Most patients have no signs or symptoms prior to a malignant hyperthermia crisis. However, nonanesthesia-related cases of severe rhabdomyolysis linked to hereditary neuromuscular disorders or RYR1 or CACNA1S mutations are reported in the literature with increasing frequency.
Jun. 07, 2021