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Effects of decrease in pyridoxal phosphate (schematic)

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Schematic diagram showing how a decrease in vitamin B6 (pyridoxine, or its activated form, pyridoxal 5'-phosphate) leads to a decrease in the conversion of the excitatory neurotransmitter glutamic acid to the inhibitory neurotransmitter GABA, which then results in seizures. Glutamic acid decarboxylase is the enzyme that catalyzes the formation of gamma-aminobutyric acid (GABA) from glutamic acid. (Diagram by Dr. Douglas J Lanska.)