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Section of subcutaneous tendinous nodule in acute rheumatic fever

Active proliferation and cell infiltration of fibrous tissue in a 7.5-year-old boy with acute rheumatic fever. Clinical features included chorea, arthritis, endocarditis, pericarditis, pleurisy, and subcutaneous nodules. Hospital for Sick Children, Great Ormond St., London. Around August 6, 1888. (Source: Cheadle WB. The acute rheumatism of childhood. In: Albutt TC, editor. A System of Medicine, by Many Writers. New York: The MacMillan Co., London: MacMillan & Co., 1898;4:38-55.)

Associated Disorders

  • Arthritis
  • Athetosis
  • Carditis
  • Chorea gravidarum
  • Obsessive-compulsive behavior
  • Rheumatic fever
  • Streptococcal pharyngitis