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Acute rheumatic fever, grave form, with numerous large subcutaneous nodules, fatal

Boy, aged 4 years and 3 months. Clinical features included rheumatic nodules, erythema marginatum, chorea, a "double mitral murmur," and arthritis. From the Hospital for Sick Children, Great Ormond St., London. Under the care of English pediatrician William Butler Cheadle (1836-1910). (Source: Cheadle WB. The acute rheumatism of childhood. In: Albutt TC, editor. A System of Medicine, by Many Writers. New York: The MacMillan Co., London: MacMillan & Co., 1898;4:38-55. Illustration restored and edited by Dr. Douglas J Lanska.)

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Associated Disorders

  • Arthritis
  • Athetosis
  • Carditis
  • Chorea gravidarum
  • Obsessive-compulsive behavior
  • Rheumatic fever
  • Streptococcal pharyngitis