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Subcutaneous nodule with superficial and deep perivascular lymphohistiocytic inflammation, extending into the subcutis from an 18-year-old man with Sydenham chorea

Hematoxylin and eosin, 2x magnification. (Source: Heard MA, Green MC, Royer M. Acute rheumatic fever: a review of essential cutaneous and histological findings. Cureus 2021;13[1]:e12577. Creative Commons Attribution [CC-BY 4.0] License,

Associated Disorders

  • Arthritis
  • Athetosis
  • Carditis
  • Chorea gravidarum
  • Obsessive-compulsive behavior
  • Rheumatic fever
  • Streptococcal pharyngitis