Thrombotic thrombocytopenic purpura: neurologic complications
Thrombotic thrombocytopenic purpura belongs to a group of disorders known as thrombotic microangiopathies. It is caused by the severe deficiency of ADAMTS13, which leads to the accumulation of ultra-large von Willebrand factor multimers that induce thrombosis. It can affect previously healthy individuals or patients with autoimmune disorders and is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and end organ damage.
Nov. 19, 2020