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CT showing asymmetric atrophy of frontal lobes in Pick-body-positive Pick disease. (Contributed by Dr. David Knopman)
Neuropharmacology & Neurotherapeutics
Jul. 25, 2021
Behavioral & Cognitive Disorders
Cognitive impairment is a common feature of multiple sclerosis and often leads to declines in the ability to initiate and carry out instrumental activities of daily living. Cognitive impairment in multiple sclerosis affects most cognitive domains, but processing speed, visual learning, and short-term memory deficits are most common. Neuropsychiatric symptoms are common, with lifetime prevalence rates of depression approaching 50%.
Jun. 09, 2020
Aug. 18, 2020
Childhood Degenerative & Metabolic Disorders
Smith-Lemli-Opitz syndrome is an autosomal recessive multiple congenital malformation that is associated with intellectual disability. The primary defect
Apr. 09, 2021
Stroke & Vascular Disorders
Intracranial atherosclerosis may be the most common cause of stroke worldwide. The neurologic syndromes associated with atherosclerotic occlusive disease of the major intracranial arteries are not unique. Other pathologies, such as cardioembolism or artery-to-artery embolism, that cause occlusions of these same arteries produce similar neurologic syndromes. Recurrent, stereotypical transient ischemic attacks should always suggest intrinsic large artery disease rather than cardioembolism.
Feb. 10, 2020
Citrullinemia is a term for 2 different inherited defects of the urea cycle: deficiency of the enzyme argininosuccinate synthetase (classic citrullinemia,
Aug. 06, 2021
Epilepsy & Seizures
West syndrome presents in infants with spasms, hypsarrhythmia on EEG, and psychomotor delay. Infantile spasms are characterized by synchronous, bilateral, brief, and sudden contractions of the axial muscle groups. It is one of the most recognized types of epileptic encephalopathy.
Nov. 03, 2020
Monoclonal antibodies (MAbs) for migraine prevention target calcitonin gene-related peptide (CGRP) receptor or CGRP itself, based on CGRP's role in migraine pathogenesis. MAbs have proven effective in preventing episodic and chronic migraine.
Mar. 24, 2021