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Progressive multifocal leukoencephalopathy (photomicrograph)

Photomicrograph of multifocal leukoencephalopathy lesion, stained with antibody to JC virus capsid antigen. Numerous oligodendrocytes are positive for the presence of JC virus (white arrows). Several bizarre astrocytes are also present; these are negative for JC virus capsid antigen (green arrows). (Contributed by Dr. John Greenlee.)

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Associated Disorders

  • Acquired immunodeficiency syndrome (AIDS)
  • Congenital combined immunodeficiency syndromes
  • HIV infection
  • Hodgkin disease
  • Immune reconstitution inflammatory syndrome
  • Immunosuppression
  • Leukemia
  • Leukemia, acute myelogenous
  • Leukemia, chronic lymphocytic
  • Leukemia, chronic myelogenous
  • Liver transplantation
  • Multiple sclerosis
  • Non-Hodgkin lymphoma
  • Nontropical sprue
  • Reticulum cell sarcoma
  • Rheumatoid arthritis
  • Sarcoidosis
  • Systemic lupus erythematosus
  • Tuberculosis