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Interactions of players in clinical trials of Alzheimer disease in the United States. (Contributed by Dr. K K Jain.)
Neuropharmacology & Neurotherapeutics
Oct. 29, 2020
General Child Neurology
Pediatric presentation of Guillain-Barré syndrome differs from that of adults with predominant symptoms of gait ataxia or pain, and a higher incidence of cranial nerve abnormalities. Weakness of the respiratory muscles can be the most serious complication. Clinical manifestations in children are often anteceded within 2 to 4 weeks by recent illness or immunization.
Nov. 23, 2020
Epilepsy & Seizures
Dec. 24, 2020
Leukemia is defined as a group of neoplasms characterized by circulating malignant cells arising from granulocytic or lymphoid precursors. Direct effects of leukemia on the nervous system include parenchymal, skull base, and meningeal metastases. Indirect effects of leukemia on the nervous system include cerebrovascular complications, such as stroke or hemorrhage from hyperviscosity syndromes, and infection or other iatrogenic complications.
Mar. 20, 2018
Neuromyelitis optica spectrum disorder (NMOSD) is a destructive, inflammatory disease of the CNS historically characterized by selective involvement of the spinal cord and optic nerves. Manifestations of NMOSD include optic neuritis, transverse myelitis, and simultaneous optic nerve and spinal cord involvement. A prodrome of headache, low-grade fever, myalgia, fatigue, upper respiratory symptoms, or gastrointestinal symptoms can precede neurologic deficits.
Feb. 23, 2021
Dravet syndrome presents with convulsive seizures in infants, followed by developmental slowing, intellectual disability, and other seizure types persisting into adulthood. Pharmacoresistance is a defining feature. Most cases are due to severe SCN1A gene mutations.
Nov. 24, 2020
Spinal meningioma is a rare tumor usually presenting with chronic progressive radicular or myelopathic symptoms and back pain. The authors discuss the
Jan. 24, 2021
Tick paralysis is a potentially fatal disease that causes rapidly ascending weakness, particularly in children. The typical presentation is with development of an unsteady, ataxic-type gait followed by an acute symmetric ascending flaccid paralysis. Clinical diagnosis is only secured by identifying an attached tick, with removal yielding rapid improvement.
Oct. 21, 2020