Stroke & Vascular Disorders
Cardiovascular procedures: neurologic complications
Jul. 21, 2021
Nearly 3,000 illustrations, including video clips of neurologic disorders.
Every article is reviewed by our esteemed Editorial Board for accuracy and currency.
Full spectrum of neurology in 1,200 comprehensive articles.
Isonicotinic acid hydrazide is a hydrazine, as is the water-soluble toxin, monomethylhydrazine. Both isonicotinic acid hydrazide and monomethylhydrazine interfere with pyridoxine metabolism, which can result in GABA depletion and refractory seizures. Like monomethylhydrazine, isonicotinic acid hydrazide metabolites directly inactivate pyridoxine species, and isonicotinic acid hydrazide also inhibits pyridoxine phosphokinase. (Public domain.)