10393 San Diego Mission Rd, Suite 120
San Diego, CA 92108-2134
Toll Free (U.S. + Canada): 800-452-2400
US Number: +1-619-640-4660
Childhood Degenerative & Metabolic Disorders
Dec. 29, 2020
Infection of the central nervous system caused by free-living amoebae is rare but usually lethal. Granulomatous amebic encephalitis is a subacute infection
Oct. 25, 2021
Behavioral & Cognitive Disorders
Korsakoff syndrome is marked by remote memory impairment together with characteristic profound anterograde memory deficits, out of proportion to dysfunction in other cognitive domains, in a person who is fully alert and responsive. Korsakoff syndrome typically results from a deficiency of thiamine and then has a characteristic pathology, making it a specific disease condition, Korsakoff disease. Korsakoff disease is frequently associated with chronic alcohol abuse, but it has also been observed in the context of a number of other conditions that cause malnutrition or malabsorption.
Oct. 21, 2020
Arachnoid cysts are classified as developmental cysts and are common incidental findings. They are usually intracranial and supratentorial in location, but spinal, and even intraneural, cysts may be identified and possibly cause symptoms. Asymptomatic cysts do not require active management. However, some are associated with seizures, local pressure effects, or hydrocephalus and may require treatment.
Mar. 21, 2019
Diabetic neuropathies include a variety of disorders that afflict diabetics fairly exclusively and are characterized by variable degrees of peripheral nerve damage. Although chronic distal sensorimotor polyneuropathy is the most common type of diabetic neuropathy, other generalized and focal acute and chronic diabetic neuropathies are not uncommonly encountered in neurologic clinical practice.
Jan. 02, 2021
The pattern of dementia in cases of sporadic amyotrophic lateral sclerosis resembles frontotemporal dementia, with behavioral alterations dominating over motor signs as a clinical feature. Patients may display changes in personality and comportment including emotional disinhibition, lack of concern, apathy, impulsiveness, emotional lability, and depression. Neuropsychological testing demonstrates severe attention deficits and impaired judgment and insight.
Feb. 11, 2020
Anti-IgLON5 disease is characterized by a distinctive sleep disorder with NREM and REM parasomnia, associated with stridor and obstructive sleep apnea. Symptoms of bulbar dysfunction, gait abnormalities, chorea, and cognitive impairment may also be present. It is associated with antibodies in serum and CSF against IgLON5.
Sep. 12, 2021
Stroke & Vascular Disorders
Carotid-cavernous fistulas are abnormal connections between the cavernous sinus and the carotid arterial system. They may present with cranial nerve palsies, and retrograde venous flow may cause orbital and ocular venous congestion. The direct variety is typically caused by head trauma or a ruptured cavernous carotid aneurysm, and presents with proptosis, ophthalmoplegia, and loss of vision. The indirect or dural variety typically occurs spontaneously in middle-aged to elderly women, and presents more subtly.
Nov. 08, 2020