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Treatment algorithm for new-onset refractory status epilepticus (NORSE) and febrile infection-related epilepsy syndrome (FIRES)

Suggested treatment algorithm. Abbreviations: IV: intravenous; IVIG: intravenous immunoglobulin; RSE: refractory status epilepticus; SE: status epilepticus; SC: subcutaneous. (Adapted from: Wickstrom R, Taraschenko O, Dilena R, et al. International consensus recommendations for management of new-onset refractory status epilepticus [NORSE] incl. febrile infection-related epilepsy syndrome [FIRES]: statements and supporting evidence. Epilepsia 2022;63[11]:2840–64.)

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Associated Disorders

  • Genetic encephalopathy
  • Infectious encephalitis
  • Paraneoplastic encephalitis
  • Postinfectious disorders
  • Primary autoimmune encephalitis