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Section of occipital cortex of a patient with progressive subcortical gliosis showing spongiform change. (hematoxylin and eosin, x40) (Contributed by Dr. Douglas Lanska.)
Jul. 20, 2021
Seizures, cortical dysplasia, tumors, intellectual disability, autism, ADHD, and sleep disorders are all CNS manifestations of tuberous sclerosis complex, occuring in about 90% of patients. Cortical dysplasia is also common, manifesting as cortical tubers and lines of migration. It is an autosomal-dominant genetic disorder.
Aug. 24, 2021
The author discusses her personal approach to treating individuals with multiple sclerosis. Choosing the optimal disease-modifying therapy is key. Treatment is changing the natural history of this disease and will, hopefully, allow most individuals to lead a normal life. Untreated, it can lead to permanent disability.
Jul. 07, 2021
Copper deficiency myeloneuropathy may have a subacute onset, presenting with a spastic gait and prominent sensory ataxia due to dorsal column dysfunction. It is the most common neurologic manifestation of acquired copper deficiency.
Feb. 26, 2021
Epilepsy & Seizures
Mitochondrial diseases that arise from defects in the respiratory chain, the metabolic pathway that produces ATP, are potent causes of epilepsy and are
Mar. 12, 2017
Headache & Pain
Neuropathic pain is defined as pain initiated or caused by a primary lesion or dysfunction in the nervous system. Central neuropathic pain is associated with CNS lesions, eg, stroke and spinal cord injury. There are several central pain syndromes with different clinical presentations and underlying neurologic abnormalities, eg, central poststroke pain, central pain in Parkinson disease, etc., and prognosis varies according to the primary pathology.
Childhood Degenerative & Metabolic Disorders
Dec. 28, 2020
Jul. 17, 2020