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Increased endomysial fibrosis and marked fiber diameter variability (photomicrograph)

Many fibers contain polymorphic dark purple masses closely associated with numerous bright red cytoplasmic bodies. (Modified Gomori trichrome) (Contributed by Dr. Enrico Bertini.)

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Associated Disorders

  • Central core disease
  • Elevated creatine kinase
  • Generalized muscle wasting
  • Joint contractures
  • Kyphoscoliosis
  • Motor weakness
  • Nemaline rod myopathy
  • Respiratory failure