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T2-weighted MRI of a patient who presented with acute episode of dizziness, diplopia, somnolence, and gait instability. (Contributed by Dr. Jose Biller.)
Jun. 10, 2020
Neuro-Ophthalmology & Neuro-Otology
Nystagmus refers to rhythmic involuntary oscillations of one or both eyes. Visual loss or ophthalmoparesis may be present. It may be physiologic or pathologic, and congenital or acquired.
Feb. 13, 2020
General Child Neurology
Childhood lead poisoning is a growing concern, particularly because new findings have shown that low-level, typical-population lead exposures are associated
Nov. 21, 2016
Mar. 16, 2021
Childhood Degenerative & Metabolic Disorders
GM1 gangliosidosis is a lysosomal storage disorder caused by a deficiency of beta-galactosidase-1. There are 3 phenotypes: infantile, juvenile, and adult. The infantile variant is the most severe form and results in neurologic impairment caused by accumulation of GM1 gangliosides, typically within the first 6 months of life. Other features include a macular cherry-red spot, coarse facies, and hepatosplenomegaly.
May. 25, 2019
Neuropharmacology & Neurotherapeutics
Nov. 02, 2020
MOG antibodies can appear in non-MS-acquired demyelinating inflammatory CNS diseases. ADEM-like disease is a common presentation in children, and neuromyelitis optica spectrum disorder, transverse myelitis, and optic neuritis characterize it in adults.
Aug. 07, 2021
Childhood CNS immune-mediated vasculitides include a broad spectrum of rare immune-mediated disorders, defined pathologically by inflammation of the vascular wall and resulting in tissue ischemia, necrosis, and inflammation. Irreversible neurologic impairment commonly occurs in this population. As these disorders may be amenable to treatment, prompt recognition by the practicing clinician has the potential to improve clinical outcomes.
Aug. 06, 2020