Hereditary spastic paraplegia
Hereditary spastic paraplegias (HSPs) are a hereditary group of disorders with intrafamilial and interfamilial variations in clinical presentations. Most cases present with a slowly progressive gait disturbance of insidious onset. Spasticity of the lower limbs, which can be slightly asymmetrical, occurs in the absence of limb weakness and is often only demonstrable on walking. Additional neurologic features such as cognitive impairment, ataxia, dysarthria, neuropathy, or seizures are seen in more than half of cases and can be the presenting feature.
Nov. 20, 2020