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This 15-year-old boy presented with fever and acute onset cauda equina syndrome. CSF was positive for mumps virus. (Contributed by Dr. Ravindra Kumar Garg.)
Neuropharmacology & Neurotherapeutics
Nov. 05, 2020
Stroke & Vascular Disorders
Nov. 08, 2020
Psychiatric disorders associated with anxiety and autonomic arousal, such as trauma-based disorders and anxiety disorders, are well known to be associated
Oct. 05, 2020
Anti-NMDA receptor encephalitis is an autoimmune disorder mediated by specific IgG autoantibodies to the GluN1 subunit of the NMDA receptor. Most patients present with neuropsychiatric symptoms that progress to include seizures, movement disorders, autonomic dysfunction, and decreased level of consciousness. The underlying mechanism of the disorder is a reversible antibody-mediated reduction of synaptic NMDA receptors.
May. 12, 2021
Behavioral & Cognitive Disorders
Alzheimer disease (AD) is a neurodegenerative disease that causes dementia, most often starting with memory loss. Its hallmark microscopic features are neurofibrillary tangles and amyloid plaques. Other symptoms may include anomia, visuospatial deficits, executive dysfunction, apathy, depression, and agitation.
Feb. 19, 2020
Sleep is a powerful enhancer of epileptic features. Synchronized non-REM sleep facilitates seizures, whereas desynchronized REM sleep dampens seizure occurrence. The presence of nocturnal seizures affects the regular profile of the sleep architecture. Sleep-related seizures mostly affect conventional sleep measures, whereas nocturnal interictal discharges basically have a destabilizing impact on cyclic alternating pattern parameters.
Jan. 28, 2020
Carbon monoxide poisoning can produce several nonspecific symptoms and can mimic several diseases. Most of the effects are due to hypoxia. Neurologic sequelae are significant and may be delayed in onset. Hyperbaric oxygen plays an important role in the management of carbon monoxide poisoning.
Mar. 28, 2021
Fingolimod, an S1P receptor modulator, has an immunosuppressant effect in patients with multiple sclerosis. The neuroprotective effect of fingolimod on relapsing-remitting multiple sclerosis may be due to its modulatory effect on oligodendroglial cells and astrocytes as well as its direct effect on cortical neurons. Adverse events during clinical trials have included bradycardia and atrioventricular block, respiratory and herpesvirus infections, increased liver enzyme levels, hypertension, and macular edema.
Jul. 27, 2021