Anti-NMDA receptor encephalitis
Anti-NMDA receptor encephalitis is an autoimmune disorder mediated by specific IgG autoantibodies to the GluN1 subunit of the NMDA receptor. Most patients present with neuropsychiatric symptoms that progress to include seizures, movement disorders, autonomic dysfunction, and decreased level of consciousness. The underlying mechanism of the disorder is a reversible antibody-mediated reduction of synaptic NMDA receptors.
May. 12, 2021