Sign Up for a Free Account

This is an image preview.
Start a Free Account
to view the full image.

Sign Up for a Free Account For information on discounts, see Plans & Pricing

  • Nearly 3,000 illustrations, including video clips of neurologic disorders.

  • Every article is reviewed by our esteemed Editorial Board for accuracy and currency.

  • Full spectrum of neurology in 1,200 comprehensive articles.

  • Listen to MedLink on the go with Audio versions of each article.

White matter injury pathophysiology

Hypoxia-ischemia and other clinical risk factors, such as infection, are key contributors to white matter injury. Mild insults selectively affect pre-oligodendrocytes (pre-OLs), which are especially vulnerable to these insults, and lead to diffuse white matter injury (as shown in purple). Severe insults result in focal necrosis with pancellular degeneration leading to cystic white matter injury (as shown in green). Abbreviations: OPC = oligodendrocyte precursor cells, pre-OLs = pre-oligodendrocytes, OL = oligodendrocyte. (Contributed by Dr. Vann Chau.)

Related Media

Associated Disorders

  • COVID-19
  • Global developmental delay
  • Hearing impairment
  • Intellectual disability
  • Neonatal hemorrhagic infarction
  • Respiratory distress syndrome
  • Seizures or epilepsy
  • Spastic diplegic cerebral palsy
  • Spastic quadriplegic cerebral palsy
  • Strabismus/visual impairment
  • norovirus
  • rotavirus