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Improved reduction in seizure frequency with neurostimulation over time

Improved reduction in seizure frequency with neurostimulation over time. Abbreviations: vagus nerve stimulation, anterior nucleus of the thalamus deep brain stimulation, responsive neurostimulation system. (Figure from: Dibue-Adjei M, Kamp MA, Vonck K. 30 years of vagus nerve stimulation trials in epilepsy: do we need neuromodulation-specific trial designs? Epilepsy Res 2019;153:71-5.)

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