General Child Neurology
Parenteral nutrition in infants and children
Mar. 29, 2024
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Toll Free (U.S. + Canada): 800-452-2400
US Number: +1-619-640-4660
Support: service@medlink.com
Editor: editor@medlink.com
ISSN: 2831-9125
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The dystroglycan protein is represented by a dumbbell-shaped structure to which sugars are sequentially added, starting with O-mannosylation of a threonine/serine site. The sites of action of 3 enzymes are shown. The sites of action of Fukutin, FKRP and LARGE are unknown, yet deficiency of these enzymes also causes dystroglycanopathy. (Adapted from Hewitt 2009.)