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The Neurotransmitters: Stiff Person Syndrome

Listen here to The Neurotransmitters: A Clinical Neurology Podcast about everything neurology! Join Dr. Michael Kentris to learn more about common clinical scenarios, the newest studies, challenging clinical cases, and more. Dr. Kentris can be found on Twitter @DrKentris or by email at

Originally released: December 23, 2022

Stiff person syndrome (SPS) is a relatively rare neurologic disorder that often causes disabling muscle spasms. After Celine Dion recently announced she was diagnosed with SPS it has received significant attention in the news. What do you need to know to answer your patients' questions about this syndrome and to potentially identify it yourself? Today we'll talk about the common symptoms, diagnostic tests, and treatments used for SPS.

Celine Dion's Instagram Post:

Stiff-Person Syndrome:

Stiff-Person Syndrome: A Treatment Update and New Directions:

Long-term effectiveness of IVIg Maintenance Therapy in 36 patients:

Evaluation of Treatment Outcomes in Patients with Stiff Person Syndrome with Rituximab vs. Standard of Care:

Find me on Twitter @Drkentris ( Email me at

The views expressed do not necessarily represent those of any associated organizations. The information in this podcast is for educational and informational purposes only and does not represent specific medical/health advice. Please consult with an appropriate health care professional for any medical/health advice.

We believe that the principles expressed or implied in the podcast remain valid, but certain details may be superseded by evolving knowledge since the episode’s original release date.

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