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  • Updated 03.08.2021
  • Released 02.23.1999
  • Expires For CME 03.08.2024

Intravenous immune globulin

Introduction

Historical note and terminology

High-dose intravenous immune globulin has been used for the treatment of autoimmune disorders since 1981, starting with idiopathic thrombocytopenic purpura (22). Although it has been used extensively in neurology during the past decade, some controversies remain about its use and mechanism of action.

Intravenous immune globulin is a purified polyvalent preparation from multiple donor plasma containing all antibodies in a concentrated form with a proportion of IgG of more than 95%. Gamunex®, 10% caprylate-chromatography purified IVIG, is an FDA-approved product.

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