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Landau-Kleffner syndrome

Landau-Kleffner syndrome (LKS) is a rare, childhood disorder of the nervous system. It features the sudden or gradual development of aphasia (the inability to understand or express language) and repeated seizures.

Children with LKS typically develop normally until signs and symptoms of the syndrome begin to develop between the ages of 2 and 8. Males are affected by LKS more often than females.

How can I or my loved one help improve care for people with Landau-Kleffner syndrome?

Consider participating in a clinical trial so clinicians and scientists can learn more about the LKS and related disorders. Clinical research uses human volunteers to help researchers learn more about a disorder and perhaps find better ways to safely detect, treat, or prevent disease.

All types of volunteers are needed—those who are healthy or may have an illness or disease—of all different ages, sexes, races, and ethnicities to ensure that study results apply to as many people as possible, and that treatments will be safe and effective for everyone who will use them.

For information about participating in clinical research visit NIH Clinical Research Trials and You. Learn about clinical trials currently looking for people with LKS at

Where can I find more information about Landau-Kleffner syndrome?

The following resource may help:

Genetic and Rare Diseases (GARD) Information Center

Content source: Accessed July 13, 2023.

The information in this document is for general educational purposes only. It is not intended to substitute for personalized professional advice. Although the information was obtained from sources believed to be reliable, MedLink, its representatives, and the providers of the information do not guarantee its accuracy and disclaim responsibility for adverse consequences resulting from its use. For further information, consult a physician and the organization referred to herein.

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