Neuroimmunology
Autoimmune sensorineural hearing loss
May. 26, 2023
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Toll Free (U.S. + Canada): 800-452-2400
US Number: +1-619-640-4660
Support: service@medlink.com
Editor: editor@medlink.com
ISSN: 2831-9125
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At 5 years of age, this 17-year-old girl first exhibited hyperactivity and aggressive behavior, which were later associated with slow learning. At 10 years of age, left-foot dystonia appeared (the foot turning inward and downward), causing gait impairment. At 12 years of age, she developed abnormal posturing while writing ("writer's cramp") with wrist and finger flexion. At 15 years of age, she developed slowness in eating, chewing, and swallowing and unintelligible speech due to severe dysarthria. When attempting to walk, she has marked trunk flexion, scoliosis to the right, extension of both elbows, flexion of knees, and plantar flexion of both feet. She has restless movements and stereotypic touching of her ear and nose. She has difficulty sitting and prefers to lie in a fetal position. MRI showed hypointensity of the globus pallidus bilaterally ("eye-of-the-tiger" sign) on T2 images. DNA analysis confirmed mutation in the PANK2 gene. This girl is the cousin of the 28-year-old woman and sister of the 32-year-old man with tongue protrusion, who also have generalized dystonia due to PKAN and are shown on other clips. (The walking sequence is repeated to allow for complete narration.) (Contributed by Dr. Joseph Jankovic.)