Movement Disorders
Stiff-person syndrome
Stiff-person syndrome is a rare disorder that causes continuous muscle contractions with spasms, abnormal postures, and progressive disability. It is often associated with other autoimmune signs and symptoms as well as nonspecific and organ-specific autoantibodies. The symptoms of stiff-person syndrome likely relate to cortical and spinal cord hyperexcitability secondary to reduction of GABA.
Sep. 26, 2021