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Midline sagittal brain MRI of a patient with spinocerebellar ataxia type 6 demonstrating cerebellar atrophy without pontine or medullary atrophy. (Contributed by Dr. Michael Oh.)
Mar. 18, 2021
Nov. 13, 2020
General Child Neurology
Neonatal white matter injury is the leading cause of cerebral palsy and other neurocognitive deficits in preterm-born children. White matter injury is the result of the selective vulnerability of pre-oligodendrocytes in the preterm brain to hypoxia-ischemia. This vulnerability may be potentiated by inflammation. White matter injury severity and location are predictors of adverse neurodevelopmental outcomes.
Jul. 12, 2021
Dec. 08, 2020
Some neurologic disorders are more common in the elderly, and their prevalence is increasing with higher life expectancies. Although changes in the brain that are associated with aging cannot be prevented, the onset of the impairment of function can be delayed, and neuropsychological performance can be improved by certain measures, including mental and physical exercises. Neurorehabilitation is important in the management of neurologic disorders of the elderly, with an emphasis on gait training.
Sep. 09, 2020
Childhood Degenerative & Metabolic Disorders
GLUT1 deficiency syndrome is a metabolic disorder due to defective transport of glucose across the blood-brain barrier. The classic picture is that of a child with refractory seizures starting in infancy, developmental delay, acquired microcephaly, hypotonia, and a movement disorder typically consisting of ataxia, spasticity, and dystonia. Increasingly, milder phenotypes are being recognized, including patients with normal cognition, early-onset absence or other generalized epilepsy, paroxysmal dystonia, or other movement disorders with and without epilepsy.
Oct. 21, 2020
Defecation and micturition syncopes are forms of the so-called situational syncopes, which occur immediately after precipitating situations, such as urination and defecation. There may be associated brief jerking or rhythmic movements, but there is no associated incontinence, tongue biting, or postictal state. Recovery usually occurs within seconds without vasomotor or other sequelae. Patients are amnestic for the period of lost consciousness.