Intracranial nongerminomatous germ cell tumors
Nov. 23, 2021
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Muscle biopsy in a 6-month-old boy. Oil red O stain reveals punctate neutral lipid to be more abundant, though not excessive, in type II fibers, a reversal of the normal expected pattern often found in congenital muscle fiber-type disproportion in infancy. This biopsy fulfills all histopathological criteria of congenital muscle fiber-type disproportion and, in the absence of any recognized associated metabolic or genetic diseases, is confirmatory of congenital muscle fiber-type disproportion as an isolated congenital myopathy. Magnification x 250. (Contributed by Dr. Harvey Sarnat.)