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Schematic location and functioning of the PCFT in the proximal jejumun and colon

In the diagram, an apical surface of polarized epithelial cells is marked by irregular contour.

Legend: DHF: dihydrofolate; 5-formyl-THF: 5-formyl-tetrahydrofolate; H+: hydrogen ion (proton); 5-methyl-THF = 5-methyl-tetrahydrofolate; 5,10-methylene-THF: 5,10-methylene-tetrahydrofolate; monoGlu: monoglutamate; Na+: sodium ion; PCFT: proton-coupled folate transporter; polyGlu: polyglutamate; THF: tetrahydrofolate. (Source: Shulpekova Y, Nechaev V, Kardasheva S, et al. The concept of folic acid in health and disease. Molecules 2021;26(12):3731.) (Modified by Dr. Douglas Lanska. Creative Commons Attribution 4.0 [CC BY] license.)

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