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Reaction schematic of the reduction of 5,10-methylene-THF to 5-methyl-THF catalyzed by MTHFR

Legend: 5-methyl-THF: 5-methyl-tetrahydrofolate; 5,10-methylene-THF: 5,10-methylenetetrahydrofolate; MTHFR: methylenetetrahydrofolate reductase; NADPH: nicotinamide adenine dinucleotide phosphate (the reduced form of NADP⁺). (Public domain.)