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Revised diagnostic algorithm for patients with suspected white matter disease

P = pathogenic, LP = likely pathogenic, UOA = urine organic acids, VLCFA = very long chain fatty acids. (From: Vanderver A, Bernard G, Helman G, et al. Randomized clinical trial of first-line genome sequencing in pediatric white matter disorders. Ann Neurol 2020;88(1):264-73.)

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