Lissencephaly is a congenital disorder of cortical development wherein cerebral convolutions are absent and the surface of the brain is smooth. Patients suffer from severe intellectual disability, hypotonia, motor delay, and seizures. More than 25 syndromes have lissencephaly as a feature. Miller-Dieker syndrome is one of the more common of these and is characterized by facial changes.
Jun. 01, 2020