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Pontine lacune causing dysarthria-clumsy hand syndrome. (Contributed by Dr. Catalina Ionita.)
Stroke & Vascular Disorders
Aug. 27, 2021
Behavioral & Cognitive Disorders
Alzheimer disease (AD) is the most common cause of late-life dementia; it can begin either in individuals aged 65 years or less (early onset) or after
Oct. 28, 2013
General Child Neurology
Literature focused on the physiologic mechanisms of cerebral edema in the pediatric population is limited and often extrapolated from the adult population;
Mar. 11, 2019
Neuropharmacology & Neurotherapeutics
Nov. 02, 2020
Headache & Pain
Aug. 22, 2021
Apraxia refers to the inability to produce skilled movements as the result of brain damage, and does not affect unlearned, basic movements. Limb kinetic apraxia, ideokinetic or ideomotor, and ideational apraxia are the major subtypes. The most frequent etiology for apraxia is stroke, but it can also be observed in diseases including brain tumors, head injury, corticobasal syndrome, Alzheimer disease, progressive supranuclear palsy, and other degenerative illnesses.
Jul. 22, 2021
Lamotrigine, an anticonvulsant drug, acts mainly by inhibiting excitatory amino acid (glutamate) release through the blockade of sodium channels and stabilizing neuronal membranes. It has a neuroprotective effect after cerebral ischemic insult.
Sep. 16, 2020
Natalizumab, an effective therapy for multiple sclerosis, can lead the ordinarily innocuous JC virus to cause progressive multifocal leukoencephalopathy (PML) if it is too potent in its ability to block ingress of T cells into the CNS. It binds to very late activation antigen-4 (VLA-4) on immune cells, which no longer bind to CNS endothelium and can’t cross the blood-brain barrier. It lowers the number of CSF T cells by at least 10-fold and B cells by 6-fold.
Jul. 23, 2021