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Gross specimens showing pigmentation in substantia nigra and locus ceruleus

(Left) Horizontal sections through the midbrain and pons of a 79-year-old male (control) and (right) 79-year-old male patient with Parkinson disease. Note the difference in pigmentation of the substantia nigra and locus ceruleus.

Associated Disorders

  • Dementia with Lewy bodies
  • Essential tremor
  • REM sleep behavior disorder