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Chemical biology in ALS-FTD

The interaction between dipeptide repeat polypeptides (DPRs), tethering of mitochondria to the endoplasmic reticulum by the VAPB-PTPIP51 tethering proteins, calcium and glycogen synthase beta gene (GSK-3b), resulting in impaired synaptic function and neurodegeneration in C9orf72 mutations ALS-FTD. (Contributed by Dr. Peter K Panegyre.)

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Associated Disorders

  • Alzheimer disease
  • Creutzfeldt-Jakob disease
  • Familial amyotrophic lateral sclerosis
  • Frontotemporal dementia
  • Frontotemporal lobar degeneration
  • Pick disease