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Histopathologic findings in a patient with anti-TIF1γ-positive antibody cancer-associated dermatomyositis

Histopathologic findings in a patient with anti-TIF1γ-positive antibody cancer-associated dermatomyositis (modified Gomori trichrome staining; bar: 50 µm). Vacuoles visible in vacuolated fibers correspond to irregularly shaped areas of myofibrillar loss (white arrows); these are not the rimmed vacuoles usually seen in sporadic inclusion body myositis. (Contributed by Werner Stenzel Charité Universitatsmedizin Berlin Dept Neuropathology.)