Jun. 02, 2021
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Muscle biopsy in mildly affected muscles shows variation of fiber size, thin atrophic fibers, central nuclei, internal structural changes, and endomysial fibrosis. In the target tibialis anterior muscle, there are frequently rimmed vacuoles (though this is not a consistent finding) and rare necrotic fibers. Rimmed vacuoles can be seen in other muscles. (Contributed by Dr. Duaa Jabari.)