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MRI pattern A1 (early-infantile Krabbe disease) (1)

White matter changes are prominent in the central region (small white arrows in lower images), cerebellar white matter (white arrows in upper images), and signal changes of the dentate nucleus (black arrows in upper images). T2-weighted magnetic resonance images in axial section (lower images), coronal section (upper left), and sagittal section (upper right). This patient had onset at 2 months and was 5 months of age at MRI. (Source: Krieg SI, Krägeloh-Mann I, Groeschel S, et al. Natural history of Krabbe disease: a nationwide study in Germany using clinical and MRI data. Orphanet J Rare Dis 2020;15[1]:243. Creative Commons Attribution 4.0 International [CC BY 4.0] license,

Associated Disorders

  • Adult globoid cell leukodystrophy
  • Diffuse brain-sclerosis
  • Diffuse gliosis
  • Early infantile globoid cell leukodystrophy
  • Juvenile globoid cell leukodystrophy
  • Late infantile globoid cell leukodystrophy
  • Leukodystrophy