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German neuropsychiatrist Karl Bonhöffer (1868-1948). (Courtesy of the U.S. National Library of Medicine and Wikipedia, public domains.)
Aug. 02, 2020
Neuroleptic malignant syndrome (NMS) is a life-threatening condition that should be suspected in any patient taking a dopamine receptor-blocking drug who has a high fever or decline in level of alertness. DSM IV criteria for diagnosing NMS include severe rigidity and fever accompanied by 2 of 10 minor features, including diaphoresis, dysphagia, tremor, incontinence, altered mentation, mutism, tachycardia, elevated or labile blood pressure, leukocytosis, and elevated creatine phosphokinase.
Mar. 13, 2021
Childhood Degenerative & Metabolic Disorders
Gaucher disease is a storage disorder caused by mutations in the GBA1 gene. Neuronopathic Gaucher disease has a very wide clinical spectrum--from congenital and early infantile Gaucher disease type 2 to very mild with horizontal supranuclear gaze palsy as the only neurologic abnormality and normal or even superior intelligence. GBA1 mutations are a risk factor for developing neurodegenerative diseases.
Dec. 28, 2019
Jul. 07, 2021
Jul. 26, 2021
Bell palsy is an acute, usually unilateral mononeuropathy of the seventh cranial nerve. The disorder is presumed to be inflammatory and associated with one of several different viral etiologies, usually herpes simplex virus-1. Features of Bell palsy include impairment of voluntary movement of facial and platysmal muscles, facial muscles pulled to the opposite side on smiling, saliva and food collected on the paralyzed side, and on attempting to close the eye, the eyeball is diverted upward and slightly outwards to avoid corneal exposure (Bell phenomenon).
Sep. 09, 2020
Neuropharmacology & Neurotherapeutics
May. 15, 2021
Sep. 18, 2020