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Overview of muscle lipid myopathies

Schematic representation of the main lipid disorders that affect the skeletal muscle cell. ATP: adenosine triphosphate, CACT: carnitine-acylcarnitine translocase, CPTI: carnitine palmitoyltransferase I, CPT II: carnitine palmitoyltransferase II, ETF: electron transfer flavoprotein, ETFDH: electron transfer flavoprotein dehydrogenase, FADH2: flavin adenine dinucleotide, FFA: free fatty acids, IMM: internal mitochondrial membrane, LCFAT: long-chain fatty acid transporter, MCAD: medium-chain acyl-CoA dehydrogenase, MTP: mitochondrial trifunctional protein, NADH: nicotinamide adenine dinucleotide, OCTN2: organic cation/carnitine transporter 2, OMM: outer mitochondrial membrane, SCAD: short-chain acyl-CoA dehydrogenase, TCA: tricarboxylic acid, VLCAD: very long-chain acyl-CoA dehydrogenase. (Contributed by Dr. Ezequiel Piccione.)

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