Neuropharmacology & Neurotherapeutics
Sumatriptan is indicated for acute treatment of migraine attacks with and without aura, and acute treatment of cluster headache episodes. It is a selective agonist of serotonin 5-HT1-like receptors including 5-HT1B/1D subtypes, and causes vasoconstriction of large cerebral blood vessels. It usually does not cross the blood-brain barrier to produce effects on the central nervous system, but some adverse effects on the brain may be due to impairment of blood-brain barrier during migraine attack.
Mar. 10, 2021