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The markedly enlarged optic nerve reaches the globe. Tumor infiltration would be evident on funduscopic examination. (Contributed by Dr. Sherman Stein.)
Jan. 07, 2021
Creutzfeldt-Jakob disease (CJD) is a member of the group of diseases known as prion diseases or the subacute spongiform encephalopathies. CJD is a subacute fatal disease with a clinical triad of dementia, myoclonus, and EEG abnormalities that is usually associated with other neurologic signs, along with neuropathological evidence of neuronal loss, spongiform changes, and astrocytosis.
Apr. 23, 2021
Mar. 29, 2020
Nov. 30, 2020
Sarcoidosis is a multisystem granulomatous disease of unknown etiology. Neurologic manifestations may occur in 10% of patients with sarcoidosis, either in addition to systemic sarcoidosis or as an isolated presentation, and may be the first clinical manifestation of sarcoidosis. Over 50% of patients with neurosarcoidosis have cranial neuropathy at initial presentation. Optic and facial nerves are most commonly involved.
Apr. 26, 2020
Oct. 21, 2020
Mar. 18, 2021
Kennedy disease is a rare, X-linked inherited, neurodegenerative disorder characterized by a progressive weakness of the proximal limbs and bulbar muscles, muscle atrophy, fasciculations (especially perioral), loss of reflexes, tremor, gynecomastia, and diabetes mellitus. It results from an excessive number of trinucleotide (CAG) repeats in the androgen receptor gene on the X chromosome. Due to its X-linked genetic association, males are predominantly affected.
Jan. 27, 2021