Coronal section of cerebrum of adult with schizencephaly

Headache associated with acute substance use or exposure

Substance headache is a headache that develops de novo with the use or exposure of a substance. The clinical manifestations of these headaches are variable and depend on the substance, dose, and duration of exposition. Headache frequently improves or resolves after substance withdrawal. The exception is carbon monoxide poisoning, wherein neurologic disturbance, particularly in the occipital areas or cerebellum, can leave permanent dysfunction.