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Diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype in a teenager

Progression of Axial T2 MRI findings in a 13-year-old male with a diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype. (a, b) Obtained at time of diagnosis, MRI shows a diffuse, expansile T2 hyperintense signal that involved the corpus callosum and extended into the right cerebral hemisphere and cortical spinal tracts. (c, d) At the completion of radiation, MRI showed a slight increase in the T2/FLAIR hyperintensity in the subcortical white matter of the frontal lobes. (e, f) Two months after radiation, the tumor showed increased infiltration into the left cerebral hemisphere with midline shift to 11 mm. (g, h) After 8 months of this therapy, there was a significant decrease in enhancement along the corpus callosum, left peritrigonal white matter, and the centrum semiovale. (Contributed by Dr. Elizabeth Finch.)

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Associated Disorders

  • Anaplastic astrocytoma
  • Anaplastic glioma
  • Diabetes insipidus
  • Glioblastoma multiforme
  • Growth hormone deficiency
  • High-grade astrocytoma
  • High-grade glioma
  • Li-Fraumeni syndrome
  • Malignant astrocytoma