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Anaplastic transformation and pathological variation over time

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Note pathologic changes in one patient with pleomorphic xanthoastrocytoma and an initial presentation of a Grade 2 pleomorphic xanthoastrocytoma, which transformed to Grade 3 pleomorphic xanthoastrocytoma with anaplastic features over time, and eventual salvage treatment effect manifested with lower mitosis rates and necrosis. (Contributed by Dr. Tolga Tuncer, University of Kansas Medical Center, 2025.)